HCID 54210476, compound → HCID 69892945, compound

Participants

Reaction Steps

{4-[2-(pyrid-3-yl)ethenyl]-2-(2-methylphenyl)benzoyl}methionine (138 mg, 0.30 mmol) was heated at 100° C. for 2 hours in n-butanol (5 mL) with 1 drop of H2SO4. The reaction was evaporated to dryness, partitioned between ethyl acetate and 5% NaHCO3, washed with water and brine, and dried over Na2SO4 to provide the title compound in 86% yield. 1H NMR (CDCl3, 300 MHz) δ 0.92 (t, 3H), 1.35 (m, 2H), 1.60 (m, 2H), 1.86 (m, 1H), 2.1 (m, 9H), 4.08 (m, 2H), 4.62 (m, 1H), 5.97 (d, 1H), 7.18-8.04 (m, 1H), 8.53 (s, 1H), 8.77 (s, 1H). MS m/e 503 (M+H)+.

Provenance & Evidence