Lithium Hydroxide → HCID 23436555, compound

Participants

Reaction Steps

The product of Example 304D (241 mg, 0.62 mmol) was dissolved in methanol (5 mL) and saturated aqueous LiOH (1 mL) was added. The reaction was heated at reflux for 1 hour. The reaction mixture was then evaporated and fomlic acid (1 mL) was added to acidify the crude product to pH3. The reaction was evaporated again to remove formic acid and ethyl acetate (5 mL) and H2O (1 mL) were added to completely solubilize the reaction mixture. The aqueous layer was extracted with ethyl acetate (3×) and the ethyl acetate layers were combined and dried over Na2SO4, filtered and evaporated to give the acid (231 mg, 100%).

Provenance & Evidence