Ammonia → HCID 10626280, compound

Participants

Reaction Steps

The desired compound was prepared by saponification of the compound of Example 343A, followed by coupling with methionine methyl ester hydrochloride and saponification of the methyl ester as described above. 1H NMR (300 MHz, CDCl3) δ 8.31 (1H, d, J=9 Hz), 8.19 (1H, d, J=3 Hz), 7.90 (1H, d, J=4 Hz), 7.42 (1H, s), 7.40-7.20 (10H, m), 6.07 (1H, d, J=9 Hz), 5.08 (2H, m), 4.62 (1H, m), 2.40 (3H, s), 2.25-2.10 (5H, 2.02 (3H, s), 2.00-1.55 (2H, m). MS (DCI, NH3) m/e 541 (M+H)+. Anal calcd for C32H32N2O4S.0.50H2O: C, 69.92; H, 6.05; N, 5.10. Found: C, 69.94; H, 6.20; N, 4.90.

Provenance & Evidence