Trifluoroacetic acid → HCID 178446056, compound

Participants

Reaction Steps

The compound of Example 387B (0.25 g, 0.38 mmol) was dissolved in 10 mL dichloromethane and 3 mL trifluoroacetic acid followed by the addition of 1.5 mL of triethylsilane and the reaction stirred at room temperature for 2 hours. The solvents were evaporated and ether added followed by the addition of 6 N HCl in ether to precipitate the desired compound (0.12 g, 77%) which was collected by rapid filtration. 1H NMR (300 MHz, DMSO-d6) 0.76 (dd, 6H), 1.38 (m, 2H), 1.55 (m, 1H), 4.19 (m, 1H), 4.42 (d, 2H), 6.63 (s, 1H), 6.73 (d, 1H), 7.31-7.36 (m, 6H), 7.63 (s, 1H), 8.23 (d, 1H), 9.09 (s, 1H).

Provenance & Evidence