Lithium Hydroxide → HCID 53779144, compound

Participants

Reaction Conditions

Reaction Steps

The product of Example 389A (0.22 g, 0.51 mmoles) was dissolved in 10 mL THF/H2O (2:1), cooled to 0° C. and LiOH (0.04 g, 1.02 mmoles) added. The reaction was stirred at 0° C. for 1 h, followed by stirring at room temperature for 2 hours. The solvents were evaporated and the residue passed through a bed of silica gel and eluted with CH2Cl2:CH3OH (9:1) to afford the title compound (0.19 g, 90%) as a white solid. 1H NMR (300 MHz, DMSO-d6) 0.79 (t, 6H), 1.19 (m, 2H), 1.42 (m, 1H), 4.06 (m, 1H), 4.36 (d, 2H), 6.53 (dd, 1H), 6.81 (m, 2H), 7.04 (d, 1H), 7.17-7.31 (m, 6H), 7.59 (d, 1H), 8.46 (d, 2H).

Provenance & Evidence