1H-imidazole-2-carbaldehyde → HCID 69892500, compound

Participants

Reaction Steps

Reductive animation of N-[4-amino-2-phenylbenzoyl]-L-leucine methylester hydrochloride and imidazole-2-carboxaldehyde following similar procedures to those described for GGTI-2132 afforded after purification N-[4-(Imidazol-2-ylmethylamino)-2-phenylbenzoyl]leucine methyl ester as a white solid. 42%. mp=156-160° C. 1H NMR (DMSO-d6) 8.19 (m, 1H, aryl), 7.58 (s, 2H), 7.34-7.22 (m, 6H), 6.67 (d, 1H, J=8.3 Hz), 6.60 (s, 1H), 4.72 (s, 2H, CH2), 4.17 (m, 1H), 3.59 (s, 3H), 1.52-1.35 (m, 3H), 0.80 (d, 3H, J=5.3 Hz), 0.75 (d, 3H, J=5.04 Hz).

Provenance & Evidence