2-Phenylpyridine → 2-(2-Bromophenyl)pyridine

Participants

Reaction Conditions

Reaction Steps

2-Phenylpyridine 3 g(19.3 mmol) and iron powder 40 mg(0.716 mmol) were mixed and stirred. Bromine 4.0 g (25 mmol) was added dropwise with stirring at 0° C., avoiding the rising temperature. Then the mixture was heated up to 90° C. and keep the temperature for ten hours with stirring. After the completion of the reaction, this reaction mixture was dissolved into chloroform solution and washed with 5% aqueous sodium thiosulfate solution. After dried by sodium sulufate, the organic solution was concentrated by an evaporator. The residue obtainedwas purifiedbyuse of silica gel column chromatography. 1.6 g (6.83 mmol) of 2-(bromophenyl)pyridine was obtained and the yield was 35.4%. Analysis: M+=234.0 By FD-MS.

Provenance & Evidence