(3R,5R)-3,5-Bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy4-methylenecyclohexanecarboxylic Acid Methyl Ester → [(3R,5R)-3,5-Bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy4-methylenecyclohexyl]methanol

HRID 2121323Notes

Reaction equation

HRID 2121323 reaction equation
[H-].C([Al+]CC(C)C)C(C)C.C[O:12][C:13]([C:15]1([OH:38])[CH2:20][C@@H:19]([O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[C:18](=[CH2:29])[C@H:17]([O:30][Si:31]([C:34]([CH3:37])([CH3:36])[CH3:35])([CH3:33])[CH3:32])[CH2:16]1)=O>CCOCC>[Si:22]([O:21][C@H:19]1[C:18](=[CH2:29])[C@H:17]([O:30][Si:31]([C:34]([CH3:37])([CH3:36])[CH3:35])([CH3:33])[CH3:32])[CH2:16][C:15]([CH2:13][OH:12])([OH:38])[CH2:20]1)([C:25]([CH3:27])([CH3:28])[CH3:26])([CH3:24])[CH3:23]

Participants

4

Reactant 2

HCID 10502782(3R,5R)-3,5-Bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy4-methylenecyclohexanecarboxylic Acid Methyl EsterHCID 21225700Diisobutylaluminumhydride

Product 1

HCID 10787320[(3R,5R)-3,5-Bis[(tert-butyldimethylsilyl)oxy]-1-hydroxy4-methylenecyclohexyl]methanolYield 24%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Conditions

Temperature
-24 °C

Procedure

Diisobutylalurninum hydride (1.5 M in toluene, 2.0 mL, 3 mmol) was added to a solution of the ester 3 (215 mg, 0.5 mmol) in anhydrous ether (3 mL) at −78° C. under argon. The mixture was stirred at −78° C. for 3 h and at −24° C. for 1.5 h, diluted with ether (10 mL) and quenched by the slow addition of 2N potassium sodium tartrate. The solution was warmed to room temperature and stirred for 15 min, then poured into brine and extracted with ethyl acetate and ether. The organic extracts were combined, washed with diluted (ca. 1%) HCl, and brine, dried (MgSO4) and evaporated. The crystalline residue was purified by flash chromatography. Elution with hexane/ethyl acetate (9:1) gave crystalline diol 4 (43 mg, 24%).

Workup

  1. customquenched by the slow addition of 2N potassium sodium tartrate
  2. temperatureThe solution was warmed to room temperature
  3. stirringstirred for 15 min
  4. additionpoured into brine
  5. extractionextracted with ethyl acetate and ether
  6. washwashed
  7. additionwith diluted (ca. 1%) HCl, and brine
  8. dry with materialdried (MgSO4)
  9. customevaporated
  10. customThe crystalline residue was purified by flash chromatography
  11. washElution with hexane/ethyl acetate (9:1)

Sources & evidence

ORD record
ord-e691e231850644f18b6b5dee9adc45d8
Source dataset
uspto-grants-2004_02
Patent number
US06696431B2

Reaction notes

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