HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 23433059, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | N,N-Diethyl-1,3-propanediamine | HCID 61011 | — |
| Reactant | tert-Butyl 2-chloropyridine-4-carboxylate | HCID 2762480 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | HCID 67132910 | HCID 67132910 | — |
| Product | HCID 23433059 | HCID 23433059 | — |
Reaction Steps
1.02 g (4.77 mmol) of tert-butyl 2-chloroisonicotinate, 5 ml of 3-diethylamino-1-propylamine, 0.66 g (4.77 mmol) of potassium carbonate, a spatula tip of Cu powder and a spatula tip of 18-crown-6 were refluxed for 4 hours. Flash chromatography of the reaction mixture (toluene/tetrahydro-furan/methanol, 4/1/1+2.5% triethylamine) resulted in 0.69 g of pale brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06696437B1 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-023225fe5f9d45259b1ec278f328c147 |
| Source note | uspto-grants-2004_02 |