7-Bromo-3-trifluoromethyl-imidazo[1,2-B][1,2,4]triazine → 5,2'-Difluoro-5'-(3-trifluoromethylimidazo[1,2-b][1,2,4]triazin-7-yl)biphenyl-2-carbonitrile

Participants

Reaction Steps

7-Bromo-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine was coupled with 5′-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-5,2′-difluorobiphenyl-2-carbonitrile as described in Example C to give 68.7 mg (46%) of 5,2′-difluoro-5′-(3-trifluoromethylimidazo[1,2-b][1,2,4]triazin-7-yl)biphenyl-2-carbonitrile as a yellow solid: mp 200-201° C.; 1H NMR (360 MHz, CDCl3) δ7.25-7.34 (2H, m), 7.44 (1H, t, J8.9 Hz), 7.87 (1H, dd, J5.4, 8.6 Hz), 8.18-8.26 (2H, m), 8.63 (1H, s), 8.82 (1H, s); MS (ES+) m/z 401. Anal. Found: C, 55.98; H, 2.13; N, 17.49%. Required for C19H8F5N5.0.3H2O: C, 56.11; H, 2.13; N, 17.22%.

Provenance & Evidence