5-chloro-N-cyclopropylmethoxy-3,4-difluoro-2-(4-iodo-2-methylphenylamino)-benzamide → Ci-1040

HRID 2121384Notes

Reaction equation

HRID 2121384 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[C:23]([F:24])=[C:22]([F:25])[C:21](Cl)=[CH:20][C:11]=1[C:12]([NH:14][O:15][CH2:16][CH:17]1[CH2:19][CH2:18]1)=[O:13].IC1C=CC(NC2C(F)=C(F)C(Cl)=CC=2C(NOCC2CC2)=O)=CC=1.IC1C=CC(NC2C(F)=C(F)C(Cl)=CC=2C(O)=O)=CC=1.ClC1C=C(I)C=CC=1NC1C(F)=C(F)C(Cl)=CC=1C(O)=O.ClC1C(F)=C(F)C(NC2C=CC(I)=CC=2C)=C(C=1)C(O)=O.ClC1C(F)=C(F)C(NC2C=CC(I)=CC=2C)=C(C=1)C(NOCC1CC1)=O>>[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[C:23]([F:24])=[C:22]([F:25])[CH:21]=[CH:20][C:11]=1[C:12]([NH:14][O:15][CH2:16][CH:17]1[CH2:19][CH2:18]1)=[O:13]

Participants

7

Reactant 6

HCID 222715295-chloro-N-cyclopropylmethoxy-3,4-difluoro-2-(4-iodo-2-methylphenylamino)-benzamideHCID 222716432-(2-chloro4-iodophenylamino)-5-chloro-N-cyclopropylmethoxy-3,4-difluorobenzamideHCID 222859232-(2-Chloro4-iodophenylamino)-5-chloro-3,4-difluorobenzoic acidHCID 222861745-Chloro-3,4-difluoro-2-(4-iodo-2-methylphenylamino)-benzoic acidHCID 222863222-(4-Iodophenylamino)-5-chloro-3,4-difluorobenzoic acidHCID 234332002-(4-iodophenylamino)-N-cyclopropylmethoxy-5-chloro-3,4-difluorobenzamide

Product 1

HCID 6918454Ci-1040

Procedure

Additional preferred compounds include 2-(2-chloro4-iodophenylamino)-5-chloro-N-cyclopropylmethoxy-3,4-difluorobenzamide (PD 297189), 2-(4-iodophenylamino)-N-cyclopropylmethoxy-5-chloro-3,4-difluorobenzamide (PD 297190), 2-(4-iodophenylamino)-5-chloro-3,4-difluorobenzoic acid (PD 296771), 2-(2-chloro4-iodophenylamino)-5-chloro-3,4-difluorobenzoic acid (PD 296770), 5-chloro-3,4-difluoro-2-(4-iodo-2-methylphenylamino)-benzoic acid (PD 296767); and 5-chloro-N-cyclopropylmethoxy-3,4-difluoro-2-(4-iodo-2-methylphenylamino)-benzamide (PD 298127).

Sources & evidence

ORD record
ord-2163dc61da6c47d9a8504318fc181f2c
Source dataset
uspto-grants-2004_02
Patent number
US06696440B1

Reaction notes

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