HRID2121384

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1cc(I)ccc1Nc1c(C(=O)NOCC2CC2)cc(Cl)c(F)c1F

HCID22271529

未命名化合物

PRODUCTS

生成物

结构：O=C(NOCC1CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl

HCID6918454

C.I. 1040

C17H14ClF2IN2O2

PROCEDURE

实验过程

Additional preferred compounds include 2-(2-chloro4-iodophenylamino)-5-chloro-N-cyclopropylmethoxy-3,4-difluorobenzamide (PD 297189), 2-(4-iodophenylamino)-N-cyclopropylmethoxy-5-chloro-3,4-difluorobenzamide (PD 297190), 2-(4-iodophenylamino)-5-chloro-3,4-difluorobenzoic acid (PD 296771), 2-(2-chloro4-iodophenylamino)-5-chloro-3,4-difluorobenzoic acid (PD 296770), 5-chloro-3,4-difluoro-2-(4-iodo-2-methylphenylamino)-benzoic acid (PD 296767); and 5-chloro-N-cyclopropylmethoxy-3,4-difluoro-2-(4-iodo-2-methylphenylamino)-benzamide (PD 298127).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2163dc61da6c47d9a8504318fc181f2c
来源数据集: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06696440B1
来源说明: uspto-grants-2004_02

反应 SMILES

[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[C:23]([F:24])=[C:22]([F:25])[C:21](Cl)=[CH:20][C:11]=1[C:12]([NH:14][O:15][CH2:16][CH:17]1[CH2:19][CH2:18]1)=[O:13].IC1C=CC(NC2C(F)=C(F)C(Cl)=CC=2C(NOCC2CC2)=O)=CC=1.IC1C=CC(NC2C(F)=C(F)C(Cl)=CC=2C(O)=O)=CC=1.ClC1C=C(I)C=CC=1NC1C(F)=C(F)C(Cl)=CC=1C(O)=O.ClC1C(F)=C(F)C(NC2C=CC(I)=CC=2C)=C(C=1)C(O)=O.ClC1C(F)=C(F)C(NC2C=CC(I)=CC=2C)=C(C=1)C(NOCC1CC1)=O>>[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[C:23]([F:24])=[C:22]([F:25])[CH:21]=[CH:20][C:11]=1[C:12]([NH:14][O:15][CH2:16][CH:17]1[CH2:19][CH2:18]1)=[O:13]