Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxindole | HCID 321710 | — |
| Reactant | HCID 10560772 | HCID 10560772 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 5353975 | HCID 5353975 | 65% |
Reaction Steps
A mixture of 133.15 mg (1 mmol) of 2-indolinone, 228.3 mg (1.2 mmol) of 4-(1-formylpiperazin-4-yl)benzaldehyde and 3 drops of piperidine in 2 ml of ethanol was stirred at 90° C. for 5 hr. After cooling, the precipitate was filtered, washed with cold ethanol and dried to yield 199.5 mg (65%) of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06696448B2 |
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| Source dataset | uspto-grants-2004_02 |
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| ORD ID | ord-5d0439ed65f54685acc01fb916888e85 |
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| Source note | uspto-grants-2004_02 |
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