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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2121439Generated: October 30, 2026

Oxindole → HCID 5353975, compound

https://huagongshe.com/reaction/2121439

Reaction equation

Participants

RoleNameHCIDCharge
ReactantOxindoleHCID 321710—
ReactantHCID 10560772HCID 10560772—
CatalystPiperidineHCID 8082—
SolventEthanolHCID 702—
ProductHCID 5353975HCID 535397565%

Reaction Conditions

Temperature90 °C

Reaction Steps

A mixture of 133.15 mg (1 mmol) of 2-indolinone, 228.3 mg (1.2 mmol) of 4-(1-formylpiperazin-4-yl)benzaldehyde and 3 drops of piperidine in 2 ml of ethanol was stirred at 90° C. for 5 hr. After cooling, the precipitate was filtered, washed with cold ethanol and dried to yield 199.5 mg (65%) of the title compound as a yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06696448B2
Source datasetuspto-grants-2004_02
ORD IDord-5d0439ed65f54685acc01fb916888e85
Source noteuspto-grants-2004_02