HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl acetoacetate → Methyl 2-[(2-chloro-4-fluorophenyl)methylene]-3-oxobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | 2-Chloro-4-fluorobenzaldehyde | HCID 145024 | — |
| Reactant | Piperidine, acetate | HCID 9793820 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-[(2-chloro-4-fluorophenyl)methylene]-3-oxobutanoate | HCID 57252060 | — |
Reaction Steps
50 g (315 mmol) of 2-chloro-4-fluoro-benzaldehyde and 36.6 g (315 mmol) of methyl acetoacetate are dissolved in 150 ml of isopropanol and admixed with 1.7 ml of piperadine acetate. The mixture is stirred at room temperature overnight and then diluted with methylene chloride and extracted with water, dried over sodium sulphate and concentrated. The crude product is reacted further, as cis-trans mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06696451B1 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-f675262d25f245ec942c621efab08b4c |
| Source note | uspto-grants-2004_02 |