HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Diethyl N-[4-(aminomethyl)benzoyl]-L-glutamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Diethyl-N-[4-[[N-(tert-butyloxycarbonyl)amino]methyl]benzoyl]-L-glutamate | HCID 15292991 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Diethyl N-[4-(aminomethyl)benzoyl]-L-glutamate | HCID 10472190 | 88.2% |
Reaction Steps
About 1.8 ml trifluoroacetic acid was added dropwise to a stirred solution containing about 1.0 g of Compound 34 in about 20 ml CH2Cl2. The mixture was stirred at room temperature for 15 minutes, evaporated to dryness under reduced pressure, and coevaporated twice with about 30 ml absolute ethanol. The residue was then subjected to column chromatography on silica gel (1.5×15 cm), eluting with a gradient of 5-10% methanol in CHCl3 to yield about 0.68 g of Compound 35.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06696455B1 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-da2d63adcd90446caeb063cca5574866 |
| Source note | uspto-grants-2004_02 |