Methanol → HCID 9951113, compound
Reaction equation
[OH:1][C@@H:2]1[C:11]2[C:10]([CH2:12][O:13][CH3:14])=[CH:9][N:8]3[C:15]([CH3:19])=[C:16]([CH3:18])[N:17]=[C:7]3[C:6]=2[NH:5][C@H:4]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C@H:3]1[OH:26].S(=O)(=O)(O)O.[CH3:32]O>O.[OH-].[Na+]>[OH:26][C@H:3]1[C@@H:2]([O:1][CH3:32])[C:11]2[C:10]([CH2:12][O:13][CH3:14])=[CH:9][N:8]3[C:15]([CH3:19])=[C:16]([CH3:18])[N:17]=[C:7]3[C:6]=2[NH:5][C@@H:4]1[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1Participants
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
180 mg of (7R,8R,9R)-7,8-dihydroxy-6-methoxymethyl-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine, dissolved in 10 ml of methanol, are admixed with 110 mg of concentrated sulfuric acid and allowed to stand at room temperature for 16 hours. The mixture is then diluted with 100 ml of water and adjusted to pH 8 using aqueous IN sodium hydroxide solution and aqueous saturated sodium hydrogen carbonate solution and extracted 3 times with in each case 50 ml of methylene chloride. The combined organic phases are evaporated to dryness in vacuo and the residue is chromatographed on silica gel (mobile phase: methylene chloride/methanol=100/3). This gives 100 mg of the title compound [Rf=0.62 (methylene chloride/methanol=13/1)] of melting point 126-9° C. (decomp.).
Workup
- extractionaqueous saturated sodium hydrogen carbonate solution and extracted 3 times with in each case 50 ml of methylene chloride
- customThe combined organic phases are evaporated to dryness in vacuo
- customthe residue is chromatographed on silica gel (mobile phase: methylene chloride/methanol=100/3)
Sources & evidence
- ORD record
- ord-5ce2889df0d74526a07017a76bb2ba0e
- Source dataset
- uspto-grants-2004_02
- Patent number
- US06696461B2
Reaction notes
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