HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylcyclopropane → 2,4-Dioxo-1,5-bis-(cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | 1H-1,5-Benzodiazepine-2,4(3H,5H)-dione | HCID 283534 | — |
| Product | 2,4-Dioxo-1,5-bis-(cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine | HCID 22312482 | — |
Reaction Steps
2,4-Dioxo-1,5-bis-(cyclopropylmethyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine was prepared following General Procedure 4-M using the product from Example 4-P, Step A, and (bromomethyl)cyclopropane (Lancaster). Purification was by flash chromatography eluting with EtOAc/hexanes (3:7 gradient to straight EtOAc), then recrystalization from EtOAc/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06696438B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-e40885fc9b5940709e99ee43cb93ee72 |
| Source note | uspto-grants-2004_02 |