Ethylenediamine → HCID 22034136, compound

Participants

Reaction Steps

To a stirred solution of 3-(2,6-dichlorophenyl)-7-chloro-2,5-dimethylpyrazolo[4,3-d]pyrimidine (652 mg, 2.0 mmol) in acetonitrile (50 mL) at 50° C., add ethylene diamine (2.4 g, 40 mmol) in one portion. Maintain the reaction at 50° C. for 2 h, cool to ambient temperature and remove the volatiles by evaporation. Partition the residue between CH2Cl2 (50 mL) and 1N NaOH (50 mL) and extract the aqueous layer with CH2Cl2 (2×30 mL). Wash the combined organic extracts with water (30 mL), brine (30 mL), dry over MgSO4 and evaporate to obtain the title compound.

Provenance & Evidence