Isobutyryl chloride → HCID 69561203, compound

Participants

Reaction Steps

To a stirred, cold (0° C.) solution of 5-(2-Methyl-4-phenyl-oxazol-5-yl)-pyridin-2-yl-hydrazine in 0.5 mL of dichloromethane and 0.3 mL of DMF and 0.325 mL of N,N-diisopropylethylamine was added 0.02 mL of isobutyryl chloride. After 5 minutes an additional 0.005 mL of isobutyryl chloride was added and the reaction was quenched a minute later with water. The mixture was extracted with dichloromethane (3×), washed with water (2×), brine (1×), dried (sodium sulfate), filtered, and the filtrate was concentrated to a dark orange oil. This oil was purified by flash chromatography (eluting with 5:1 ethyl acetate/hexanes) to give 23 mg of isobutyric acid N′-[5-(2-methyl-4-phenyl-oxazol-5-yl)-pyridin-2-yl]-hydrazide as an orange solid.

Provenance & Evidence