Hydrazine → 5-Bromo-2-hydrazinopyridine

Participants

Reaction Conditions

Reaction Steps

A mixture of 22.1 g 5-bromo-2-fluoropyridine and 10 mL of 55% aqueous hydrazine in 165 mL of pyridine was heated at reflux for 7 hours. The mixture was cooled to 22° C. concentrated to near dryness. The resulting light yellow solids were suspended in aqueous sodium hydroxide and toluene, stirred, and the solids were collected by vacuum filtration to give 22 g of 5-bromo-pyridin-2-yl-hydrazine as a faint yellow solid.

Provenance & Evidence