4-(Trifluoromethyl)benzylamine → HCID 69285284, compound

HRID 2121636Notes

Reaction equation

HRID 2121636 reaction equation
[N:1]1([C:8]2[C:17]3[C:12](=[CH:13][C:14](I)=[CH:15][CH:16]=3)[N:11]=[C:10]([CH3:19])[CH:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:20][C:21]([F:31])([F:30])[C:22]1[CH:29]=[CH:28][C:25]([CH2:26][NH2:27])=[CH:24][CH:23]=1>>[N:1]1([C:8]2[C:17]3[C:12](=[CH:13][C:14]([NH:27][CH2:26][C:25]4[CH:24]=[CH:23][C:22]([C:21]([F:20])([F:30])[F:31])=[CH:29][CH:28]=4)=[CH:15][CH:16]=3)[N:11]=[C:10]([CH3:19])[CH:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 69282484HCID 69282484, compound

Product 1

HCID 69285284HCID 69285284, compound

Procedure

In analogy to example 1a), on reaction of 4-azepan-1-yl-7-iodo-2-methyl-quinoline with 4-trifluoromethylbenzylamine there was obtained (4-azepan-1-yl-2-methyl-quinolin-7-yl)-(4-trifluoromethyl-benzyl)-amine a light brown solid. ISP mass spectrum, m/e: 414.3 (M+1 calculated for C24H26F3N3: 414).

Sources & evidence

ORD record
ord-b996e40605284c6ba347a6377a9d19a0
Source dataset
uspto-grants-2004_02
Patent number
US06696467B2

Reaction notes

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