(3-Methylthiophen-2-yl)methanamine → HCID 23434012, compound

HRID 2121638Notes

Reaction equation

HRID 2121638 reaction equation
I[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)=[CH:7][C:8]([CH3:12])=[N:9]2)=[CH:4][CH:3]=1.[CH3:18][C:19]1[CH:23]=[CH:22][S:21][C:20]=1[CH2:24][NH2:25]>>[CH3:12][C:8]1[CH:7]=[C:6]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:5]2[C:10](=[CH:11][C:2]([NH:25][CH2:24][C:20]3[S:21][CH:22]=[CH:23][C:19]=3[CH3:18])=[CH:3][CH:4]=2)[N:9]=1

Participants

3

Reactant 2

HCID 2798756(3-Methylthiophen-2-yl)methanamineHCID 113366637-Iodo-2-methyl-4-pyrrolidin-1-yl-quinoline

Product 1

HCID 23434012HCID 23434012, compound

Procedure

In analogy to example 1, on reaction of 7-iodo-2-methyl-4-pyrrolidin-1-yl-quinoline with 3-metylthiophene-2-metylamine there was obtained (2-methyl-4-pyrrolidin-1-yl-quinolin-7-yl)-(3-methyl-thiophen-2-ylmethyl)-amine as yellow foam. ISP mass spectrum, m/e: 338.3 (M+1 calculated for C20H23N3S: 338).

Sources & evidence

ORD record
ord-5ac2544ebf494b6c90471518b81895a3
Source dataset
uspto-grants-2004_02
Patent number
US06696467B2

Reaction notes

Loading…