Potassium Carbonate → HCID 12114194, compound

Participants

Reaction Steps

A mixture of 0.6 g (1.6 mmol) of [2-amino-1-(4-fluorophenyl)-5-pyridin-3-yl-1H-pyrrol-3-yl](hydroxyphenyl)methanone, 1.06 g (3.7 mmol) of L-α,β-isopropylideneglycerol-γ-tosylate and 1.2 g (8.7 mmol) of potassium carbonate in 10 mL of DMF was heated at 80°. After 16 h, the reaction mixture was cooled to room temperature, poured into brine and extracted with ethyl acetate. The extracts were dried over sodium sulfate, concentrated under reduced pressure and purified by flash chromatography (gradient elution: 15-50% ethyl acetate/hexane) to give 0.7 g (90%) of [2-amino-1-(4-fluorophenyl)-5-pyridin-3-yl-1H-pyrrol-3-yl]-[3-(2,2-dimethyl-[1,3 ]dioxolan-4(S)-ylmethoxy)-phenyl]-methanone.

Provenance & Evidence