Water → HCID 23434143, compound

HRID 2121727Notes

Reaction equation

HRID 2121727 reaction equation
[C:1]([C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[S:5][C:4]=1[C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1)#[N:2].[OH-:20].[K+].O>CC(O)(C)C>[N:17]1[CH:18]=[CH:19][C:14]([C:4]2[S:5][C:6]([C:8]3[CH:9]=[CH:10][N:11]=[CH:12][CH:13]=3)=[CH:7][C:3]=2[C:1]([NH2:2])=[O:20])=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 12112779HCID 12112779, compound

Product 1

HCID 23434143HCID 23434143, compoundYield 70.2%

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

A mixture of 3-cyano-2,5-di(4-pyridyl)thiophene (40 mg, 0.152 mmol), potassium hydroxide (25 mg, 0.446 mmol) in 2-methyl-2-propanol (2 mL) was heated at reflux temperature for 2 hours. After cooling, the mixture was poured into water. The precipitates were collected by filtration, and dried under reduced pressure to give the title compound (30 mg, 70% yield).

Workup

  1. temperaturewas heated
  2. temperatureat reflux temperature for 2 hours
  3. temperatureAfter cooling
  4. filtrationThe precipitates were collected by filtration
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-a02cd80cd1774e9798de8a5d9cd9424e
Source dataset
uspto-grants-2004_02
Patent number
US06696470B2

Reaction notes

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