Ethanol → 4-Ethoxycarbonylphenylboronic acid

HRID 2121739Notes

Reaction equation

HRID 2121739 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([B:10]([OH:12])[OH:11])=[CH:6][CH:5]=1)([OH:3])=[O:2].S(=O)(=O)(O)O.[CH2:18](O)[CH3:19]>>[CH2:18]([O:2][C:1]([C:4]1[CH:5]=[CH:6][C:7]([B:10]([OH:12])[OH:11])=[CH:8][CH:9]=1)=[O:3])[CH3:19]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 3121834-Carboxyphenylboronic Acid

Product 1

HCID 27343504-Ethoxycarbonylphenylboronic acid

Procedure

A solution of 4-carboxyphenylboronic acid (15 g, 0.09 mol), 99% ethanol (150 mL) and concentrated sulphuric acid (0.5 mL) was heated to reflux for two days. The volume was reduced to approximately 20 mL. The residue was triturated with petroleum ether to give 13.4 g of the desired material.

Workup

  1. temperatureto reflux for two days
  2. customThe residue was triturated with petroleum ether

Sources & evidence

ORD record
ord-273769f16344468bac056c1bb008f75a
Source dataset
uspto-grants-2004_02
Patent number
US06696475B2

Reaction notes

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