HCID 23433473, compound → 2'-Fluoro-5'-methoxy4-nitro-2-biphenylcarboxylic acid

HRID 2121781Notes

Reaction equation

HRID 2121781 reaction equation
[F:1]C1C=CC(OC)=C(C2C(C(O)=O)=CC([N+]([O-])=O)=CC=2)C=1.C[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[C:31]1[C:32]([C:41]([O:43]C)=[O:42])=[CH:33][C:34]([N+:38]([O-:40])=[O:39])=[CH:35][C:36]=1C>>[F:1][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[C:31]1[C:32]([C:41]([OH:43])=[O:42])=[CH:33][C:34]([N+:38]([O-:40])=[O:39])=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 23433473HCID 23433473, compoundHCID 234336025'-Fluoro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid

Product 1

HCID 234335282'-Fluoro-5'-methoxy4-nitro-2-biphenylcarboxylic acidYield 99%

Procedure

This compound was prepared in a manner similar to that of 5′-fluoro-2′-methoxy-4-nitro-2-biphenylcarboxylic acid (EXAMPLE 107) from methyl 2′-methyl-5′-methoxy-6-methyl-4-nitro-2-biphenylcarboxylate (0.77 g) to afford 0.73 g (99%) of 2′-fluoro-5′-methoxy-4-nitro-2-biphenylcarboxylic acid as a white solid, which was used in the next step without further purification.

Sources & evidence

ORD record
ord-916e579685994ead85e2cb44641e6e10
Source dataset
uspto-grants-2004_02
Patent number
US06696459B1

Reaction notes

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