反应详情

温度

4 °C

To a stirred solution of 4-amino-5-(4-methoxyphenoxy)quinazoline (1.0 g, 3.7 mmol) in 30 ml of dichloromethane pyridine (0.3 g, 3.7 mmol) and acetic anhydride (0.38 g, 3.7 mmol) were added at room temperature and stirring continued for 4 days. After evaporation under reduced pressure, 30 ml of 2-propanol was added and after cooling to 4° C. the solid was collected by filtration, washed, recrystallized from ethanol, filtrated again and dried at 50° C. in vacuo. to give 4-acetamido-5-(4-methoxyphenoxy)quinazoline (0.5 g, 45.4%, m.p. 174-175° C.).

1. customAfter evaporation under reduced pressure, 30 ml of 2-propanol
2. additionwas added
3. filtrationwas collected by filtration
4. washwashed
5. customrecrystallized from ethanol
6. filtrationfiltrated again
7. customdried at 50° C. in vacuo