HCID 22386581, compound → HCID 22386584, compound

Participants

Reaction Steps

4-Amino-5-(4-benzyloxyphenoxy)quinazoline (1.5 g, 4.4 mmol) was hydrogenated under 5 atm of H2 in the presence of 0.5 g of 10% Pd/C in 80 ml of N,N-dimethylacetamide at 50-60° C. After 4 hours the reaction mixture was filtered through a glass filter of silica gel, concentrated, dissolved in 80 ml of ethanol/water 4:1 (v/v) and crystallized at 4° C. The precipitate was collected by filtration, washed with ethanol and dried at 50° C. in vacuo to give 4-amino-5-(4-hydroxyphenoxy)quinazoline (0.3 g, 27.3%, m.p. 300-302° C. (dec)).

Provenance & Evidence