反应详情

Phosphorus pentoxide (10 g) is added to a suspension of N′-(2,2-dimethylpropanoyl)-3-methyl-4-nitrobenzhydrazide (5.1 g) in toluene (200 ml). After refluxing for 2 h, the reaction mixture is poured into ice-water and extracted with diethyl ether. The organic phases are combined, dried over magnesium sulphate, evaporated and purified by chromatography on silica (eluent: 2/1 diethyl ether/petroleum ether) to give 2-(1,1-dimethylethyl)-5-(3-methyl-4-nitrophenyl)-1,3,4-oxadiazole.

1. temperatureAfter refluxing for 2 h
2. extractionextracted with diethyl ether
3. dry with materialdried over magnesium sulphate
4. customevaporated
5. custompurified by chromatography on silica (eluent: 2/1 diethyl ether/petroleum ether)