HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2121839Generated: October 30, 2026
1,2,3,4-Tetrahydroisoquinoline → HCID 23434368, compound
https://huagongshe.com/reaction/2121839
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
| Reactant | 1-Chloro-2,5-dimethyl-4-nitrobenzene | HCID 252793 | — |
| Solvent | 1-Methylpyrrolidine | HCID 8454 | — |
| Product | HCID 23434368 | HCID 23434368 | — |
Reaction Steps
A mixture of 1-chloro-2,5-dimethyl-4-nitrobenzene (1.65 g) and 1,2,3,4-tetrahydroisoquinoline (5 ml) in N-methylpyrrolidine (5 ml) is stirred at 140° C. for 15 h. Dilution in water followed by extraction with diethyl ether and chromatography on silica (eluent: 1/1 petroleum ether/diethyl ether) of the dried and evaporated organic phase gives 2-(2,5-dimethyl-4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06696487B2 |
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| Source dataset | uspto-grants-2004_02 |
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| ORD ID | ord-394fcbfa9d8a434cb453da1de8272c40 |
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| Source note | uspto-grants-2004_02 |
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