HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 135843648, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 6-Benzyloxy-1-[2-(tert-butyldimethyl-silanyloxy)-propyl]-1H-indazole | HCID 22496576 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 135843648 | HCID 135843648 | 85% |
Reaction Steps
A mixture of the product from Step A (10.6 g, 27 mmol) and palladium-on-carbon (10%, 0.26 g) in methanol (250 mL) was stirred under an atmosphere of hydrogen for 6 h, dichloromethane (100 mL) was added and the mixture filtered. Evaporation of the filtrate gave an off-white solid (7.0 g, 85%): mp 169-174° C.; LC/MS (+APCI) m/z 307 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06696476B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-d91c7f6372ec47ceb92f87d3cab1dc69 |
| Source note | uspto-grants-2004_02 |