Thionyl Chloride → HCID 69702056, compound

HRID 2121912Notes

Reaction equation

HRID 2121912 reaction equation
[C:1]([O:5][C:6](=[O:31])[CH2:7][O:8][C:9]1[C:17]([CH2:18]O)=[C:16]2[C:12]([CH:13]=[N:14][N:15]2[CH2:20][C@H:21]([O:23][Si:24]([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25])[CH3:22])=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:34])=O>ClCCl>[C:1]([O:5][C:6](=[O:31])[CH2:7][O:8][C:9]1[C:17]([CH2:18][Cl:34])=[C:16]2[C:12]([CH:13]=[N:14][N:15]2[CH2:20][C@H:21]([O:23][Si:24]([C:27]([CH3:30])([CH3:29])[CH3:28])([CH3:26])[CH3:25])[CH3:22])=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl Chloride2×HCID 69712223HCID 69712223, compound

Product 1

HCID 69702056HCID 69702056, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of the product from Step A (2.78 g, 6.18 mmol) in anhydrous dichloromethane (100 mL) was added thionyl chloride (0.68 g, 9.27 mmol). After 1.5 h more thionyl chloride was added (0.23 mL) and stirring was continued for 20 min. Evaporation of this mixture under high vacuum gave an oil (2.90 g) which was used in next reaction without further purification.

Workup

  1. customEvaporation of this mixture under high vacuum

Sources & evidence

ORD record
ord-68f73d89a3f9414cb869321bd36945ee
Source dataset
uspto-grants-2004_02
Patent number
US06696476B2

Reaction notes

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