Sodium hydride → HCID 69710152, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product from Step B (2.90 g, 6.18 mmol) in anhydrous 1-methyl-2-pyrrolidone (30 mL) was added sodium hydride (60%, 0.371 g, 9.27 mmol). The mixture was heated at 50° C. overnight and at ambient temperature for 2 days, cooled and poured into a saturated aqueous solution of sodium bicarbonate (100 mL) and extracted with ethyl acetate. Chromatography on silica (gradient, 2% to 25% ethyl acetate in hexane) gave an oil (0.48 g, 18%): LC/MS (+APCI) m/z 433(M+H).

Provenance & Evidence