Dimethylcarbamoyl Chloride → HCID 73690419, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of the product of Example 57 in CHCl3 was added TEA (84 μL, 0.6 mmol) and dimethylcarbamoyl chloride (56 μL, 0.6 mmol). The resulted suspension was heated to 65° C. overnight with shaking. Solvent was removed under vacuum to give a crude, which was purified by chromatography on silica gel, eluting by MeOH-DCM (5:95) to afford the title compound (38.6 mg). 1H-NMR indicated one isomer. 1H-NMR (DMSO-d6): δ 97.73 (1H, d), 7.28-7.39 (7H, m), 7.14 (1H, d), 6.97 (1H, dd), 6.63 (1H, dd), 5.12 (2H, s), 4.98 (1H, t), 3.78 (3H, s), 3.05 (6H, m), 2.91 (3H, s), 0.99 (3H, t); MS (ESI): 585 (MH+).

Provenance & Evidence