4-Hydroxy-3-Nitroacetophenone → HCID 73855073, compound

HRID 2121956Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[N+:11]([O-])=O.C1(C)C=CC(S([O-])(=O)=O)=CC=1.[CH2:25]([N:32]1[C:36](=[O:37])[C:35](=[C:38]2[N:42]([CH3:43])[C:41]3[CH:44]=[CH:45][CH:46]=[CH:47][C:40]=3[S:39]2)[S:34][CH2+:33]1SC)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[C:3]([N:11]=[C:33]2[N:32]([CH2:25][C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:36](=[O:37])[C:35](=[C:38]3[N:42]([CH3:43])[C:41]4[CH:44]=[CH:45][CH:46]=[CH:47][C:40]=4[S:39]3)[S:34]2)[CH:4]=1)(=[O:10])[CH3:9]

Participants

Reactant 1

HCID 1387234-Hydroxy-3-Nitroacetophenone

Product 1

HCID 73855073HCID 73855073, compound

Procedure

In a manner similar to Example 30, 4′-hydroxy-3′-nitroacetophenone was hydrogenated and then condensed with 3-benzyl-5-(3-methyl-3H-benzothiazol-2-ylidene)-2-methylthio-4-oxo-2-thiazolium p-toluenesulfonate to afford the title compound. MS(ESI): 488 (MH+).

Sources & evidence

ORD record: ord-1225ba5172bf4d3486cc42031e511571
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06696473B2

Reaction notes

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