HCID 21937596, compound → HCID 73855042, compound

HRID 2121971Notes

Reaction equation

[CH2:1]([NH:3][C:4]1[CH:20]=[CH:19][C:7]([NH:8][C:9](=[O:18])[CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[CH:6][C:5]=1[N+:21]([O-])=O)[CH3:2].C1(C)C=CC(S([O-])(=O)=O)=CC=1.[CH2:35]([N:42]1[C:46](=[O:47])[C:45](=[C:48]2[N:52]([CH3:53])[C:51]3[CH:54]=[CH:55][CH:56]=[CH:57][C:50]=3[S:49]2)[S:44][CH2+:43]1SC)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH2:35]([N:42]1[C:46](=[O:47])[C:45](=[C:48]2[N:52]([CH3:53])[C:51]3[CH:54]=[CH:55][CH:56]=[CH:57][C:50]=3[S:49]2)[S:44][C:43]1=[N:21][C:5]1[CH:6]=[C:7]([NH:8][C:9](=[O:18])[CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)[CH:19]=[CH:20][C:4]=1[NH:3][CH2:1][CH3:2])[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1

Participants

Reactant 1

HCID 21937596HCID 21937596, compound

Product 1

HCID 73855042HCID 73855042, compound

Procedure

In a manner similar to Example 30, intermediate 4′-ethylamino-2-(4-methylpiperazin-1-yl)-3′-nitroacetanilide was hydrogenated and then condensed with 3-benzyl-5-(3-methyl-3H-benzothiazol-2-ylidene)-2-methylthio-4-oxo-2-thiazolium p-toluene sulfonate to afford the title compound. MS(ESI): 628 (MH+).

Sources & evidence

ORD record: ord-6b94bc5d4981430d8757afb850d884a9
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06696473B2

Reaction notes

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