Methanol → HCID 73855136, compound

Participants

Reaction Steps

To a 50 mL flask was added the product of Example 157 (0.19 g, 0.32 mmol), CHCl3 (5 mL), MeOH (10 mL), water (2 mL), and potassium carbonate (0.22 g, 1.6 mmol). After 4 h the reaction mixture was diluted with CHCl3 (40 mL), and the organic phase was partitioned, washed with water (20 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure. The crude sample was chromatographed (silica gel, 0-10% MeOH/DCM) to afford the title compound (37 mg, 21%). 1H-NMR (CDCl3): δ 8.14 (1H, s), 7.42-7.48 (3H, m), 7.27-7.33 (5H, m), 7.15 (1H, t), 7.09 (1H, dd), 6.99 (1H, d), 6.56 (1H, d), 5.15 (2H, s), 4.14 (2H, s), 3.71 (3H, s), 2.95 (2H, q), 0.99 (3H, t); MS(ESI): 546 (MH+).

Provenance & Evidence