Methyl p-toluenesulfonate → 2-[2'-(5-Acetyl-2-ethylaminophenylimino)-3'-benzyl-5-methyl-4'-oxo-4-phenyl-3',4'-dihydro-2'H-[2,5']bithiazolyliden-3-yl]ethyl Acetate

Participants

Reaction Steps

In a manner similar to that described in Example 52, intermediate 2-(5-methyl-4-phenyl-2-thioxothiazol-3-yl)ethyl acetate was alkylated with methyl p-toluenesulfonate and condensed with 2-(5-acetyl-2-ethylaminophenylimino)-3-benzylthiazolidin-4-one to yield the title compound. 1H-NMR (CDCl3): δ 7.63-7.67 (2H, m), 7.44-7.51 (5H, m), 7.28-7.37 (5H, m), 6.50 (1H, d), 5.19 (2H, s), 4.30 (1H, br t), 4.03 (4H, m), 3.06 (2H, m), 2.48 (3H, s), 2.05 (3H, s), 1.89 (3H, s), 1.05 (3H, t); MS(ESI): 627 (MH+).

Provenance & Evidence