HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-Mercapto-3-nitrophenyl)acetamide → N-(3-Amino-4-sulfanylphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-Mercapto-3-nitrophenyl)acetamide | HCID 21937525 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(3-Amino-4-sulfanylphenyl)acetamide | HCID 21937579 | 92.9% |
Reaction Steps
A suspension of 4′-mercapto-3′-nitroacetanilide (3.0 g, 14 mmol) and 10% Pd/C (0.6 g) in MeOH (200 mL) was hydrogenated at 60 psi overnight. The catalyst was removed by filtration, and the filtrate was concentrated to give 3′-amino-4′-mercaptoacetanilide (2.5 g, 13 mmol), which was used in the next reaction immediately.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06696473B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-6d4405f9329a4a94b74332ea2f037579 |
| Source note | uspto-grants-2004_02 |