反应详情

To a stirred solution of 4-chloro-3-nitroaniline (51.8 g, 0.36 mol) in anhydrous DCM (300 mL) was added dropwise acetic anhydride (45 mL, 0.48 mol) at room temperature, and the resulting solution was stirred at room temperature for 3 h. The solvent was removed in vacuo, and Et2O was added to the residue. The precipitates were collected by filtration, washed thoroughly with Et2O, and dried under high vacuum to give 4′-chloro-3′-nitroacetanilide (78.7 g, 100%).

1. customThe solvent was removed in vacuo, and Et2O
2. additionwas added to the residue
3. filtrationThe precipitates were collected by filtration
4. washwashed thoroughly with Et2O
5. customdried under high vacuum