Alendronate Sodium → Alendronate sodium anhydrous

HRID 2122077Notes

Reaction equation

HRID 2122077 reaction equation
[CH2:1]([CH2:13][NH2:14])[CH2:2][C:3]([P:9]([O-:12])([OH:11])=[O:10])([P:5]([OH:8])([OH:7])=[O:6])[OH:4].O.O.O.[Na+:18]>C(O)C>[CH2:1]([CH2:13][NH2:14])[CH2:2][C:3]([P:5]([O-:7])([OH:8])=[O:6])([P:9]([OH:12])([OH:11])=[O:10])[OH:4].[Na+:18]

Participants

3

Reactant 1

HCID 23681107Alendronate Sodium

Product 1

HCID 16760285Alendronate sodium anhydrousYield 107.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of alendronate sodium trihydrate 1.0 g (3.08 mmol) in aqueous ethanol (10 ml of ethanol+1.9 ml of water) was boiled at reflux with stirring for 15 hrs. After cooling to ambient temperature the solid was filtered, washed with absolute ethanol and ether, and dried overnight in a vacuum oven (10-15 mm Hg, ambient temperature) to give 0.9 g of alendronate sodium, containing crystal form G.

Workup

  1. temperatureat reflux
  2. filtrationwas filtered
  3. washwashed with absolute ethanol and ether
  4. customdried overnight in a vacuum oven (10-15 mm Hg, ambient temperature)

Sources & evidence

ORD record
ord-aa84ec7b3e8c4d489f6fb5a5a1907a6f
Source dataset
uspto-grants-2004_02
Patent number
US06696601B2

Reaction notes

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