HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → [(2,4-Difluoro-phenyl)-methyl-amino]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | 2,4-difluoro-N-methylaniline | HCID 2737023 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | [(2,4-Difluoro-phenyl)-methyl-amino]-acetic acid methyl ester | HCID 20627003 | — |
Reaction Steps
To a mixture of the 2,4-Difluoro-N-methylaniline (Avacado Research Chemical, Heysham UK) (1.43 g, 10 mmole) in NMP, and K2CO3, was added methyl bromoacetate (0.945 ml, 10 mmole) and stirred at room temperature for 24 hours. The reaction mixture was added to water and extracted with ethyl acetate (3×50 ml), the organic extracts were washed 6× with water, dried (MgSO4) amd evaporated to give the product as a oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06696566B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-dbc2e752867a4f52ac44b58bf8199368 |
| Source note | uspto-grants-2004_02 |