Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl morpholine oxide | HCID 82029 | — |
| Reactant | Methyl 2-bromo-2-(4-chlorophenyl)acetate | HCID 10777987 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 4313443 | HCID 4313443 | — |
Reaction Steps
97.2 g of a 75% strength aqueous N-methylmorpholine N-oxide solution were added with ice-cooling to a solution of 100 g (0.38 mol) of the compound of Example 1 in 400 ml of dimethyl sulfoxide (DMSO). After the mixture had been stirred for 24 hours at 20 to 25° C., it was poured into water and extracted with methyl tert-butyl ether (MtBE). After the organic phases had been dried, stripped from the solvent and chromatographed on silica gel (cyclohexane/MtBE [3:1]), 69 g of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06696607B2 |
|---|
| Source dataset | uspto-grants-2004_02 |
|---|
| ORD ID | ord-93aee7b7907a4e18a83dbb438d45307f |
|---|
| Source note | uspto-grants-2004_02 |
|---|
