Potassium Hydroxide → HCID 441116, compound

HRID 2122106Notes

Reaction equation

HRID 2122106 reaction equation
[Cl:1][C:2]([Cl:15])=[C:3]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)[C:4]([O:6]C)=[O:5].[OH-].[K+]>CO>[Cl:15][C:2]([Cl:1])=[C:3]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 11184678HCID 11184678, compound

Product 1

HCID 441116HCID 441116, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
22.5 °C

Procedure

A solution of 17.1 g (64 mmol) of the ester of Example 3 in 50 ml of methanol was treated with 193 ml of 1 N KOH solution and then stirred for 20 hours at 20 to 25° C. After the solvent had been distilled off, the residue was acidified with 20% strength H2SO4 to pH 1 and extracted with ethyl acetate. The organic phases were dried and stripped from the solvent, whereupon 15 g of the title compound were isolated.

Workup

  1. distillationAfter the solvent had been distilled off
  2. extractionextracted with ethyl acetate
  3. customThe organic phases were dried
  4. customwere isolated

Sources & evidence

ORD record
ord-411a2b8f8102437aa59e7056bcffb347
Source dataset
uspto-grants-2004_02
Patent number
US06696607B2

Reaction notes

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