4-(3-Hydroxy-1-propynyl)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone → 4-(3-Hydroxypropyl)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

Participants

Reaction Steps

4-(3-Hydroxy-1-propynyl)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (89.7 mg, 0.180 mmol) was dissolved in methanol (5.4 mL), and the solution was added with 10% Pd—C (16.8 mg), followed by stirring at room temperature for 2.7 hours under hydrogen atmosphere at normal pressure. The mixture was added with 10% Pd—C (8.9 mg), and further stirred for 2.5 hours. The reaction mixture was filtered using Celite. The solvent of filtrate was evaporated under reduced pressure to obtain 4-(3-hydroxypropyl)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (84.6 mg, yield 93%).

Provenance & Evidence