HRID21225

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COCC#Cc1ccc(-c2cc3cc(CN4CCCCC4)ccc3n2C(=O)OC(C)(C)C)c2c1CNC2=O

HCID131728236

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

HCID68492207

未命名化合物

收率 96%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

In a similar manner to Step 1 of Example 328, 4-(3-methoxy-1-propinyl)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (157 mg, 0.306 mmol) was dissolved in methanol (6.3 mL), and the solution was added with 10% Pd—C (46 mg) to react hydrogen. The reaction mixture was filtered using Celite. The solvent of the filtrate was evaporated under reduced pressure to obtain 4-(3-methoxypropyl)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (152 mg, yield 96%).

WORKUP

后处理

filtrationThe reaction mixture was filtered
customThe solvent of the filtrate was evaporated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cfb4a1b5fecc4702a1c503e75f5509fa
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07745641B2
来源说明: uspto-grants-2010_06

反应 SMILES

[CH3:1][O:2][CH2:3][C:4]#[C:5][C:6]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[C:17]3[C:22]([CH:23]=2)=[CH:21][C:20]([CH2:24][N:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[CH:19][CH:18]=3)=[C:11]2[C:7]=1[CH2:8][NH:9][C:10]2=[O:38].[H][H]>CO.[Pd]>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]([C:31]([O:33][C:34]([CH3:36])([CH3:35])[CH3:37])=[O:32])[C:17]3[C:22]([CH:23]=2)=[CH:21][C:20]([CH2:24][N:25]2[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]2)=[CH:19][CH:18]=3)=[C:11]2[C:7]=1[CH2:8][NH:9][C:10]2=[O:38]