Methyl 4-[bromo(3-cyanophenyl)methyl]benzoate → Methyl 4-[(3-cyanophenyl)-[3-[1-(3,5-difluorophenyl)-2-fluoro-2-methylpropyl]azetidin-1-yl]methyl]benzoate
Reaction equation
[Br:1][CH:2]([c:3]1[cH:4][cH:5][c:6]([C:7](=[O:8])[O:9][CH3:10])[cH:11][cH:12]1)[c:13]1[cH:14][c:15]([C:19]#[N:20])[cH:16][cH:17][cH:18]1.[F:21][c:22]1[cH:23][c:24]([CH:29]([C:30]([CH3:31])([CH3:32])[F:33])[CH:34]2[CH2:35][NH:36][CH2:37]2)[cH:25][c:26]([F:28])[cH:27]1>>[CH:2]([c:3]1[cH:4][cH:5][c:6]([C:7](=[O:8])[O:9][CH3:10])[cH:11][cH:12]1)([c:13]1[cH:14][c:15]([C:19]#[N:20])[cH:16][cH:17][cH:18]1)[N:36]1[CH2:35][CH:34]([CH:29]([c:24]2[cH:23][c:22]([F:21])[cH:27][c:26]([F:28])[cH:25]2)[C:30]([CH3:31])([CH3:32])[F:33])[CH2:37]1Participants
3
Sources & evidence
- ORD record
- ord-9195a20c0f8d4e1e83d19aaf2641f1f7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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