Bicarbonate Ion → 4-(4-Bromo-3-fluorobenzyl)morpholine

HRID 2123326Notes

Reaction equation

HRID 2123326 reaction equation
[Br:1][c:2]1[c:3]([F:10])[cH:4][c:5]([CH:6]=[O:7])[cH:8][cH:9]1.[C:17]([O:18][BH-:19]([O:20][C:21](=[O:22])[CH3:23])[O:24][C:25](=[O:26])[CH3:27])(=[O:28])[CH3:29].[CH2:11]1[CH2:12][O:13][CH2:14][CH2:15][NH:16]1.[Cl:38][CH:39]([Cl:40])[CH3:41].[Cl:42][CH2:43][Cl:44].[K+:37].[Na+:30].[Na+:35].[O-:31][C:32]([OH:33])=[O:34].[OH-:36].[OH2:45]>>[Br:1][c:2]1[c:3]([F:10])[cH:4][c:5]([CH2:6][N:16]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[cH:8][cH:9]1

Participants

11

Reactant 10

HCID 769Bicarbonate IonHCID 813Potassium CationHCID 923Sodium ion2×HCID 961HydroxideHCID 962WaterHCID 6344DichloromethaneHCID 63651,1-DichloroethaneHCID 8083MorpholineHCID 2724942TriacetoxyborohydrideHCID 27834114-Bromo-3-fluorobenzaldehyde

Product 1

HCID 534178184-(4-Bromo-3-fluorobenzyl)morpholine

Sources & evidence

ORD record
ord-4bf18a3db0e3406ca3805368c4fb0670
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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