2-Methoxyphenylboronic acid → 5-(6-Fluoro-2'-methoxybiphenyl-3-yl)-2-trifluoromethyl[1,8]-naphthyridine

HRID 2123718Notes

Reaction equation

HRID 2123718 reaction equation
[CH3:30][O:31][c:32]1[c:33]([B:38]([OH:39])[OH:40])[cH:34][cH:35][cH:36][cH:37]1.[F:1][c:2]1[c:3]([O:22][S:23]([C:24]([F:25])([F:26])[F:27])(=[O:28])=[O:29])[cH:4][c:5](-[c:8]2[cH:9][cH:10][n:11][c:12]3[n:13][c:14]([C:18]([F:19])([F:20])[F:21])[cH:15][cH:16][c:17]23)[cH:6][cH:7]1>>[F:1][c:2]1[c:3](-[c:33]2[c:32]([O:31][CH3:30])[cH:37][cH:36][cH:35][cH:34]2)[cH:4][c:5](-[c:8]2[cH:9][cH:10][n:11][c:12]3[n:13][c:14]([C:18]([F:19])([F:20])[F:21])[cH:15][cH:16][c:17]23)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 27339582-Methoxyphenylboronic acidHCID 86594178Trifluoromethanesulfonic acid 2-fluoro-5-(7-trifluoromethyl[1,8]naphthyridin-4-yl)phenyl ester

Product 1

HCID 101354765-(6-Fluoro-2'-methoxybiphenyl-3-yl)-2-trifluoromethyl[1,8]-naphthyridine

Sources & evidence

ORD record
ord-39b9c736acfd422a85fe2be7425f1509
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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