Methanol → 2-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenylamino)-4-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzo[d]thiazol-6-ol

HRID 2124320Notes

Reaction equation

HRID 2124320 reaction equation
[BH4-:33].[CH3:35][OH:36].[Cl:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[c:8]([O:31][CH3:32])[cH:9][c:10]([NH:13][c:14]3[s:15][c:16]4[c:17]([n:18]3)[CH:19]([c:24]3[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]3)[CH2:20][C:21](=[O:23])[CH2:22]4)[cH:11][cH:12]2)[cH:6]1.[Na+:34]>>[Cl:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[c:8]([O:31][CH3:32])[cH:9][c:10]([NH:13][c:14]3[s:15][c:16]4[c:17]([n:18]3)[CH:19]([c:24]3[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]3)[CH2:20][CH:21]([OH:23])[CH2:22]4)[cH:11][cH:12]2)[cH:6]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 28123BorohydrideHCID 581100012-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenylamino)-4-(4-fluorophenyl)-4,5-dihydrobenzo[d]thiazol-6(7H)-one

Product 1

HCID 581099972-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenylamino)-4-(4-fluorophenyl)-4,5,6,7-tetrahydrobenzo[d]thiazol-6-ol

Sources & evidence

ORD record
ord-f263d4b162ca4f1e9c529823be5e21ef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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