Dimethyl Sulfoxide → N2'-(trans-4-aminocyclohexyl)-3-chloro-5'-fluoro-N6-((tetrahydro-2H-pyran-4-yl)methyl)-2,4'-bipyridine-2',6-diamine

HRID 2124479Notes

Reaction equation

HRID 2124479 reaction equation
[CH3:32][S:33]([CH3:34])=[O:35].[CH:24]1([NH2:31])[CH2:25][CH2:26][CH:27]([NH2:30])[CH2:28][CH2:29]1.[Cl:1][c:2]1[c:3](-[c:16]2[cH:17][c:18]([F:23])[n:19][cH:20][c:21]2[F:22])[n:4][c:5]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[cH:6][cH:7]1>>[Cl:1][c:2]1[c:3](-[c:16]2[cH:17][c:18]([NH:31][CH:24]3[CH2:25][CH2:26][CH:27]([NH2:30])[CH2:28][CH2:29]3)[n:19][cH:20][c:21]2[F:22])[n:4][c:5]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 679Dimethyl SulfoxideHCID 183741,4-DiaminocyclohexaneHCID 669369493-Chloro-2',5'-difluoro-N-[(oxan-4-yl)methyl][2,4'-bipyridin]-6-amine

Product 1

HCID 50907862N2'-(trans-4-aminocyclohexyl)-3-chloro-5'-fluoro-N6-((tetrahydro-2H-pyran-4-yl)methyl)-2,4'-bipyridine-2',6-diamine

Sources & evidence

ORD record
ord-0705da25e9694ee7a39dd26038cfcab1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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